.h1,
.h2,
.h3,
.h4,
.h5,
.h6,
h1,
h2,
h3,
h4,
h5,
h6 {
  font-weight: 700;
}

body {
  overflow-x: hidden !important;
}

.quantum-footer__inner {
  max-width: 1265px;
  padding: 6px 14px;
  width: 100%;
  margin: auto;
  display: flex;
  flex-direction: row-reverse;
  justify-content: flex-end;
  align-items: center;
}

.footerMain-copyright {
  width: 33%;
  margin-right: 20px;
  display: flex;
  justify-content: flex-start;
  gap: 15px;
  align-items: center;
}

.footerMain-copyright img {
  width: 78.2px;
  height: 20px;
}

.quantum-footer__links-row {
  position: relative;
}

#footer-logo {
  display: none;
  /* position: absolute;
      right: 0;
      top: 30px;*/
}

#footer-logo img {
  width: 106px;
}

.quantum-link.quantum-footer__link {
  color: #505050 !important;
  font-size: 14px;
  font-weight: 400;
  line-height: 17px;
  text-decoration: underline;

  padding-right: 10px;
  padding-left: 10px;
}

.top-menu .top-menu-c {
  display: flex;
  justify-content: space-between;
}

.top-menu .top-menu-c ul:first-of-type {
  list-style: none;
  padding-left: 0;
}

.top-menu .top-menu-c ul:first-of-type li {
  font-size: 14px;
  padding-top: 10px;
}

.quantum-link.quantum-footer__link:first-child {
  padding-left: 0px;
}

.last-link {
  border-right: 0px solid #505050 !important;
}

.footerMain-copyright p {
  color: #505050;
  font-size: 12px;
  font-weight: 400;
  line-height: 16px;
  margin-bottom: 0;
}

@media screen and (max-width: 767px) {
  footer {
    padding-bottom: 50px;
  }

  .quantum-footer__links-row {
    position: unset;
  }

  .quantum-footer__inner {
    position: relative;
    padding: 6px;
  }

  #footer-logo {
    position: absolute;
    right: 0;
    left: 0;
    top: unset;
    bottom: -20px;
  }

  .quantum-link.quantum-footer__link {
    margin-bottom: 1rem;
    display: inline-block;
  }
}

.quantum-footer {
  padding: 0px 15px 0px 15px;
}

#opensFullIsi,
#closesFullIsi,
.quantum-indications__close {
  display: none;
}

.quantum-indications__title {
  margin: 0;
}

.anchor-jump-links {
  background-color: #eeeeee;
  padding-top: 5px;
  padding-bottom: 5px;
  min-height: 40px;
  max-width: 100%;
}

.anchor-jump-links .link-list ul {
  display: -ms-flexbox;
  display: flex;
  -ms-flex-wrap: wrap;
  flex-wrap: wrap;
  padding-left: 0;
  margin-bottom: 0;
  list-style: none;
  justify-content: center;
  align-items: center;
}

.anchor-jump-links .link-list ul li {
  text-align: center;
  padding: 4px 0;
}

.anchor-jump-links .link-list ul li a {
  position: relative;
  display: block;
  color: #505050;
  font-size: 14px;
  /* text-transform: uppercase;*/
  text-decoration: none;
  padding-right: 20px;
  padding-left: 20px;
  padding-top: 10px;
  padding-bottom: 10px;
}

.aranesp .anchor-jump-links .link-list ul li a:hover,
.aranesp .anchor-jump-links .link-list ul li a.active {
  background-color: #d9531e;
  border-radius: 40px;

  color: #fff;
  font-weight: 600;
}

.epogen .anchor-jump-links .link-list ul li a:hover,
.epogen .anchor-jump-links .link-list ul li a.active {
  background-color: #f03d42;
  border-radius: 40px;

  color: #fff;
  font-weight: 600;
}

.home .anchor-jump-links .link-list ul li a:hover,
.home .anchor-jump-links .link-list ul li a.active {
  background-color: #00bce4;
  border-radius: 40px;

  color: #fff;
  font-weight: 600;
}

.support-and-services .anchor-jump-links .link-list ul li a:hover,
.support-and-services .anchor-jump-links .link-list ul li a.active {
  background-color: #00bce4;
  border-radius: 40px;

  color: #fff;
  font-weight: 600;
}

ul.quantum-drop-down-menu__list {
  display: -ms-flexbox;
  display: flex;
  -ms-flex-direction: row;
  flex-direction: row;
  padding-left: 0;
  margin-bottom: 0;
  list-style: none;
  align-items: center;
  width: 100%;
  justify-content: flex-end;
  gap: 32px;
  margin-top: 10px;
  position: relative;
  z-index: 1;
}

li.quantum-drop-down-menu__list-item:last-child {
  display: flex;
  flex-direction: row;
  justify-content: center;
  align-items: center;
  gap: 10px;
  padding: 10px 40px 10px 25px;
  border-radius: 10000px;
  background-color: #0063c3;
  cursor: pointer;
}

li.quantum-drop-down-menu__list-item:last-child a {
  font-family: Roboto;
  font-size: 16px;
  font-weight: normal;
  font-stretch: condensed;
  font-style: normal;
  line-height: 1.5;
  letter-spacing: normal;
  text-align: left;
  color: #fff;
  border-bottom: 0;
  padding: 0;
  text-decoration: none;
  margin-bottom: 0 !important;
}

li.quantum-drop-down-menu__list-item:last-child a:hover {
  border-bottom: none;
}

li.quantum-drop-down-menu__list-item:last-child a::after {
  content: "";
  display: block;
  width: 7.4px;
  height: 12px;
  background-image: url("/~/media/Themes/Amgen/Amgenesas-com/Amgenesas-com/images/white-arrow");
  background-repeat: no-repeat;
  background-size: cover;
  position: absolute;
  right: 19px;
  top: 50%;
  transform: translateY(-50%);
}

a.quantum-home-nav.quantum-drop-down-menu__link {
  color: #505050;
  font-size: 16px;
  font-weight: 400;
  padding: 0.5rem 0px;
  border-bottom: 4px solid transparent;
  text-decoration: none;
}

.home ul.quantum-drop-down-menu__list li:first-child,
ul.quantum-drop-down-menu__list li:first-child:hover {
  border-bottom: 4px solid #00bce4;
  text-shadow: 0 0 0.7px #505050, 0 0 0.7px #505050;
  text-decoration: none;
}

.aranesp ul.quantum-drop-down-menu__list li:nth-child(2),
ul.quantum-drop-down-menu__list li:nth-child(2):hover {
  border-bottom: 4px solid #d9531e;
  text-shadow: 0 0 0.7px #505050, 0 0 0.7px #505050;
  text-decoration: none;
}

.epogen ul.quantum-drop-down-menu__list li:nth-child(3),
ul.quantum-drop-down-menu__list li:nth-child(3):hover {
  border-bottom: 4px solid #f03d42;
  text-shadow: 0 0 0.7px #505050, 0 0 0.7px #505050;
  text-decoration: none;
}

.support-and-services ul.quantum-drop-down-menu__list li:nth-child(4),
ul.quantum-drop-down-menu__list li:nth-child(4):hover {
  border-bottom: 4px solid #00bce4;
  text-shadow: 0 0 0.7px #505050, 0 0 0.7px #505050;
  text-decoration: none;
}

.hero-div {
  clear: both;
}

.home .home-risk-txt {
  margin: 48px 0;
}

.home #standard-of-care {
  padding-top: 64px;
}

.home #standard-of-care #banner-sub-hd .component-content h4 {
  font-weight: normal;
}

.quantum-header .quantum-header__inner .quantum-header__left {
  display: flex;
  align-items: center;
}

.quantum-header__inner {
  display: flex;
}

.quantum-header__right {
  width: 100%;
  padding-left: 0%;
}

header.header-nav>div:first-of-type {
  max-width: 1280px;
}

.top-menu>div:first-of-type {
  max-width: 1280px;
}

@media (min-width: 992px) {
  header.header-nav {
    margin-top: 10px;
  }

  .aranesp header.header-nav {
    margin-top: 25px;
  }

  li.quantum-drop-down-menu__list-item {
    max-width: 240px;
  }

  /*  li.quantum-drop-down-menu__list-item:first-child {
                                  padding-left: 10%;
                  } */
  .quantum-header__mobile-content {
    display: none;
  }
}

@media screen and (max-width: 991px) {
  .quantum-footer__links-row {
    width: 100%;
    display: flex;
    flex-direction: column;
    justify-content: flex-start;
    text-align: left;
  }

  .quantum-footer__inner {
    flex-direction: column;
    padding: 0;
  }

  .quantum-link.quantum-footer__link {
    border-right: none;
  }

  .footerMain-copyright {
    width: 100%;
    margin-right: 0;
  }

  .quantum-footer {
    padding: 0 8px;
  }

  a.quantum-header__logo {
    width: 140px;
  }

  button.quantum-button.quantum-button--tertiary.quantum-header__icon-button.quantum-button--large.quantum-button--icon-only {
    display: none;
  }

  button.quantum-button.quantum-button--tertiary.quantum-header__icon-button.quantum-header__menu-trigger.quantum-header__menu-trigger--expand-menu {
    display: block;
    width: 46px;
    height: 40px;
    position: absolute;
    right: 0;
    border: 0;
    background: transparent;
    margin-right: 20px;
  }

  button.quantum-button.quantum-button--tertiary.quantum-header__icon-button.quantum-header__menu-trigger .quantum-icon {
    width: 100%;
    position: relative;
    height: 100%;
  }

  button.quantum-button.quantum-button--tertiary.quantum-header__icon-button.quantum-header__menu-trigger.quantum-header__menu-trigger--collapse-menu {
    width: 46px;
    height: 40px;
    position: absolute;
    right: 0;
    border: 0;
    background: transparent;
  }

  header.header-nav {
    padding: 5px 0;
  }

  .quantum-header__menu {
    position: absolute;
    left: 0;
    width: calc(100%);
    margin-left: 0;
    top: 75px;
    background-color: rgb(238, 238, 238);
    z-index: 10;
    padding: 0 12px;
    margin-top: 8px;
  }

  ul.quantum-drop-down-menu__list {
    -ms-flex-direction: column;
    flex-direction: column;
    align-items: start;
  }

  li.quantum-drop-down-menu__list-item:after {
    content: url(../images/right-arrow.png);
    position: absolute;
    right: 12px;
    font-weight: 400;
    font-size: 20px;
  }

  li.quantum-drop-down-menu__list-item {
    padding-top: 8px;
    border-bottom: 1px solid #cccccc;
    position: relative;
    display: flex;
    align-items: center;
    width: 100%;
  }

  ul.quantum-drop-down-menu__top-nav-list {
    margin: 0;
  }
  
}

@media screen and (max-width: 767px) {
  .non-dialysis .anchor-jump-links {
    top: 0 !important;
  }

  .top-menu ul.mailul {
    display: block !important;
  }

  li.quantum-drop-down-menu__list-item:last-child::after {
    content: none !important;
  }

  .anchor-jump-links .link-list ul {
    flex-direction: column;
  }

  .support-and-services .p-nav-pills ul li a.active::after {
    content: none !important;
  }
  .anchor-jump-links{
    margin-top: 30px;
  }
  .anchor-jump-links.fixed{
    margin-top: 0px;
  }
}

.line-divider {
  border-top: 1px solid #707070;
}

.no-border-section {
  border-bottom: 0px;
}

.container .container {
  padding: 0;
}

#next-page-button {
  margin-top: 3rem;
  display: none;
}

.img-syg-caption {
  position: relative;
  bottom: 24px;
  left: 64%;
}

.non-dialysis .anchor-jump-links {
  top: -30px !important;
}

section#esa-flexible-dosing {
  border-bottom: none;
  padding-bottom: 0;
  padding-top: 50px;
}

@media screen and (min-width: 768px) {
  .anemia-due-to-ckd {
    margin-top: -270px;
  }
}

.aranesp #clinical-experience h4 {
  font-weight: 500;
}

.header-nav.fixed {
  position: fixed;
  top: 0;
  left: 0;
  width: 100%;
  background-color: #ffffff !important;
  z-index: 20;
  /* transition: all 0.3s ease-in-out; */
  box-shadow: 0px 2px 4px rgb(0 0 0 / 10%);
  margin-top: 0px !important;
}

.anchor-jump-links.fixed {
  position: fixed;
  z-index: 10;
  top: 65px;
  width: 100%;
}

.non-dialysis .anchor-jump-links.fixed {
  top: 145px !important;
}

@media screen and (max-width: 767px) {

  .non-dialysis .anchor-jump-links.fixed {
    top: 0px !important;
  }

  #next-page-button .text-left {
    text-align: center !important;
  }

  .header-nav.fixed {
    position: relative !important;
    z-index: 999 !important;
  }

  .anchor-jump-links.fixed {
    top: 0 !important;
  }

  .anchor-jump-links .link-list ul li a {
    position: unset;
    font-size: 16px;
  }

  .anchor-jump-links .link-list ul li {
    position: relative;
  }

  .anchor-jump-links ul li a.active+.pills-arrow::after{
    display: inline-block;
    position: absolute;
    right: 16px;
    top: 16px;
    vertical-align: 0.255em;
    content: "";
    border-top: 0.3em solid;
    border-right: 0.3em solid transparent;
    border-bottom: 0;
    border-left: 0.3em solid transparent;
    border: solid rgba(0, 0, 0, 0.55);
    border-width: 0 3px 3px 0;
    padding: 7px;
    transform: rotate(45deg);
    -webkit-transform: rotate(45deg);
    margin-left: 10px;
  }

  .anchor-jump-links ul li a.active+.pills-arrow.rotate::after {
    transform: rotate(225deg);
    -webkit-transform: rotate(225deg);
    top: 15px;
  }
}

.back-to-top {
  z-index: 10;
}

.fa-phone {
  transform: rotate(90deg);
}

.epogen-banner-bottle {
  bottom: 35px;
}

@media screen and (max-width: 767px) {
  .epogen-banner-bottle {
    bottom: 0;
    max-width: 300px;
    left: 0;
  }
}

#esa-response {
  display: block;
  border: none;
}

/* Accordion Component Styles */
.accordion {
  width: 100%;
  border-bottom: 1px solid #c3ccd5;
  padding-bottom: 80px;
  border-top: 1px solid #c3ccd5;
  padding-top: 80px;
}

.accordion>div:first-of-type {
  max-width: 1140px;
  margin: auto;
}

.accordion .items {
  list-style: none;
  padding: 0;
  margin: 0;
}

.accordion .item {
  margin-bottom: 0;
  border-bottom: 1px solid #e0e0e0;
}

.accordion .item:last-child {
  border-bottom: none;
  box-shadow: 0 4px 16px 0 var(--opacity-neutral-10012, rgba(28, 30, 33, 0.12));
}

/* Toggle Header Styles */
.accordion .toggle-header {
  cursor: pointer;
  padding: 15px 20px;
  background-color: #f8f8f8;
  transition: background-color 0.3s ease;
  position: relative;
  user-select: none;
  outline: none;
}

.accordion .toggle-header:hover {
  background-color: #f0f0f0;
}

.accordion .toggle-header:focus {
  outline: 2px solid #0063c3;
  outline-offset: -2px;
}

.accordion .item.active .toggle-header {
  background-color: #f4f4f4;
  box-shadow: 0 4px 16px 0 var(--opacity-neutral-10012, rgba(28, 30, 33, 0.12));
}

/* Toggle Header Icon/Indicator */
.accordion .toggle-header::after {
  content: "";
  width: 55px;
  height: 30px;
  background-image: url("/~/media/Themes/Amgen/Amgenesas-com/Amgenesas-com/images/white-arrow-down.svg");
  background-repeat: no-repeat;
  background-size: cover;
  position: absolute;
  right: 20px;
  top: 26%;
  transition: transform 0.3s ease, content 0.3s ease;
}

.accordion .item.active .toggle-header::after {
  background-image: url("/~/media/Themes/Amgen/Amgenesas-com/Amgenesas-com/images/white-arrow-up.svg");
}

/* Alternative: Arrow Icon */
.accordion.accordion-arrow .toggle-header::after {
  content: "";
  width: 0;
  height: 0;
  border-left: 6px solid transparent;
  border-right: 6px solid transparent;
  border-top: 8px solid #505050;
  border-bottom: none;
  background: none;
  transform: translateY(-50%) rotate(0deg);
  transition: transform 0.3s ease;
}

.accordion .thin-line {
  display: none;
}

.accordion.accordion-arrow .item.active .toggle-header::after {
  transform: translateY(-50%) rotate(180deg);
}

/* Toggle Content Styles */
.accordion .toggle-content {
  display: none;
  padding: 20px;
  background-color: #ffffff;
  overflow: hidden;
  transition: max-height 0.3s ease;
}

.accordion .item.active .toggle-content {
  display: block;
}

/* Smooth Animation Support */
.accordion .toggle-content {
  max-height: 0;
  padding-top: 0;
  padding-bottom: 0;
  overflow: hidden;
  transition: max-height 0.5s ease, padding 0.5s ease;
}

.accordion .item.active .toggle-content {
  max-height: 10000px;
  padding-top: 20px;
  padding-bottom: 20px;
}

/* Label Styles */
.accordion .toggle-header .label {
  padding-right: 40px;
}

.accordion .toggle-header .field-heading {
  margin: 0;
  font-size: 16px;
  font-weight: bold;
  color: #505050;
}

/* Responsive Styles */
@media screen and (max-width: 767px) {
  .accordion .toggle-header {
    padding: 12px 15px;
    font-size: 16px;
  }

  .accordion {
    padding-bottom: 40px;
  }

  .accordion .toggle-header::after {
    right: 15px;
    font-size: 20px;
  }

  .accordion .toggle-content {
    padding: 15px;
  }

  .accordion .item.active .toggle-content {
    padding-top: 15px;
    padding-bottom: 15px;
  }
}

/* Accessibility: Screen Reader Support */
/* ARIA attributes are handled by JavaScript for screen reader support */

/* Disabled State */
.accordion .item.disabled .toggle-header {
  cursor: not-allowed;
  opacity: 0.6;
  pointer-events: none;
}

#clinical-experience .container .main-heading,
#clinical-experience .container:first-of-type h4:first-of-type {
  font-size: 28px;
}

#clinical-experience .container:first-of-type h4:first-of-type {
  padding-bottom: 30px;
}

.home .footnote p:last-of-type {
  margin-top: 10px;
}

.non-dialysis #dosing .footnote p {
  text-indent: 15px;
}